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Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii
Weidong He1, Miroslav Cik, Luc Van Puyvelde
1Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, Belgium.
Bioorganic & Medicinal Chemistry
|August 2, 2002
Abstract:
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.