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Substituted hexahydrobenzodipyrans as 5-HT2A/2C receptor probes
Michael S Whiteside1, Deborah Kurrasch-Orbaugh, Danuta Marona-Lewicka
1Department of Chemistry, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA.
Bioorganic & Medicinal Chemistry
|August 2, 2002
Abstract:
A pair of substituted hexahydrobenzodipyrans was designed as molecular probes for determining the steric restrictions of the agonist binding site of serotonin 5-HT2A and 5-HT2C receptors. The rationale for the design of these receptor ligands, their chemical synthesis, rat behavioral pharmacology in the two-lever drug discrimination assay using LSD-trained rats, affinity for cloned rat 5-HT2A and 5-HT2C receptors and agonist functional activities are reported.