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Lipoprotein(a): still an enigma?
Karam M Kostner1, Gerhard M Kostner
1Department of Cardiology, University Hospital of Vienna, Austria.
Current Opinion in Lipidology
|August 2, 2002
Summary
Lipoprotein(a) is highly atherogenic, with new research revealing its in-situ production and role in hemostasis. Understanding its catabolism and function may lead to novel therapeutic strategies for cardiovascular disease.
Area of Science:
- Cardiovascular Research
- Lipid Metabolism
- Atherosclerosis
Background:
- Lipoprotein(a) is a significant atherogenic lipoprotein.
- Its physiological function and catabolism remain incompletely understood despite extensive research.
Purpose of the Study:
- To review recent advances in understanding lipoprotein(a).
- To explore potential therapeutic implications of new findings.
Main Methods:
- Review of recent prospective studies.
- Analysis of findings on apolipoprotein(a) production and function.
- Evaluation of novel therapeutic strategies.
Main Results:
- High lipoprotein(a) levels are linked to increased coronary event risk.
- Apolipoprotein(a) is produced within the vessel wall and affects hemostasis.
- New antisense oligonucleotide strategies show promise in inhibiting apolipoprotein(a) expression.
- Lipoprotein(a) may also influence angiogenesis and tumor cell infiltration.
Conclusions:
- Understanding of lipoprotein(a) catabolism and physiological function is still evolving.
- Recent discoveries offer insights into pathomechanisms related to hemostasis.
- These findings provide a basis for developing new treatment strategies for elevated lipoprotein(a).