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Functions of FGF signalling from the apical ectodermal ridge in limb development

Xin Sun1, Francesca V Mariani, Gail R Martin

  • 1Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, 94143-0452, USA.

Nature
|August 2, 2002
PubMed
Summary

Fibroblast growth factors (FGF4 and FGF8) from the apical ectodermal ridge are essential for limb development by regulating cell number and survival. Their absence leads to limb formation failure in mice.

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