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Related Experiment Videos

Paratuberculosis in a mandrill (Papio sphinx).

Laura S Zwick1, Timothy F Walsh, Robyn Barbiers

  • 1Zoological Pathology Program, University of Illinois College of Veterinary Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|August 3, 2002
PubMed
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A mandrill died from Mycobacterium avium subsp. paratuberculosis infection, causing severe gastrointestinal issues and weight loss. This finding highlights the susceptibility of non-human primates to Johne's disease.

Area of Science:

  • Veterinary Pathology
  • Primate Medicine
  • Microbiology

Background:

  • Mandrills (Papio sphinx) are Old World monkeys susceptible to various diseases.
  • Johne's disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), primarily affects ruminants but can impact other species.
  • Captive wildlife require ongoing health monitoring for emerging infectious diseases.

Observation:

  • A 2.5-year-old female mandrill presented with chronic abdominal bloat, diarrhea, and significant weight loss.
  • Necropsy revealed emaciation and severe gastrointestinal distention.
  • Histopathology showed granulomatous enterocolitis and lymphadenitis with abundant acid-fast bacilli.

Findings:

  • Mycobacterium avium subsp. paratuberculosis (MAP) was confirmed in fecal, ileal, and colonic samples via radiometric culture and IS900 PCR.

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  • Concurrent findings included myocardial and vascular amyloidosis, interstitial pneumonia, and glossal candidiasis.
  • The presence of massive acid-fast bacilli within macrophages indicated a severe systemic infection.

    • Implications:

    • This case confirms MAP infection in a mandrill, expanding the known host range for this pathogen.
    • It underscores the importance of diagnostic testing for Johne's disease in non-ruminant captive wildlife.
    • Further research into MAP transmission dynamics and pathogenesis in primates is warranted.