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Histamine-dependent changes in free radical processes during coronary heart disease
1Department of Internal Diseases No 2, Therapeutic Faculty, I. M. Sechenov Moscow Medical Academy.
Bulletin of Experimental Biology and Medicine
|August 3, 2002
Abstract:
Histamine is involved in the pathogenesis of coronary heart disease, intensifies generation of reactive oxygen species by blood leukocytes, and causes mobilization followed by exhaustion of antioxidant reserves. The prooxidant effect of histamine on free radical processes in patients with coronary heart disease determines the rate of recurrences and is associated with poorer prognosis and more severe course of the disease.