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Updated: Sep 30, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient
Ravi D Rao1, Jerry W Swanson, Ramona S Dejesus
1Division of Hematology and Internal Medicine, Rochester, MN 55905, USA.
Abstract:
A 27-year-old woman with acute lymphoblastic leukemia (ALL) had an episode of generalized tonic-clonic seizure after therapy with intrathecal and intravenous methotrexate (MTX). Magnetic resonance imaging (MRI) of her head showed meningeal, cortical and subcortical enhancement that was new when compared to a study done prior to therapy. Subsequent imaging 10 days later showed partial resolution of these findings. The association of seizures and MTX in ALL and the corresponding MRI changes are discussed.
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