Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory mechanisms in posttraumatic stress disorder.

Barry Layton1, Robert Krikorian

  • 1Department of Physical Medicine and Rehabilitation, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA. blayton@metrohealth.org

The Journal of Neuropsychiatry and Clinical Neurosciences
|August 3, 2002
PubMed
Summary

This study proposes a new neurobiological theory for posttraumatic stress disorder (PTSD) memory. It suggests the amygdala consolidates traumatic memories and inhibits the hippocampus during arousal, affecting peritraumatic memory.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The state of the science on the health benefits of blueberries: a perspective.

Frontiers in nutrition·2024
Same author

Reply to Lee, S.Y. Comment on "Krikorian et al. Early Intervention in Cognitive Aging with Strawberry Supplementation. <i>Nutrients</i> 2023, <i>15</i>, 4431".

Nutrients·2024
Same author

Early Intervention in Cognitive Aging with Strawberry Supplementation.

Nutrients·2023
Same author

Detecting mild cognitive impairment remotely with the modified memory impairment screen by telephone.

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition·2023
Same author

Blueberry Supplementation in Midlife for Dementia Risk Reduction.

Nutrients·2022
Same author

Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial.

Clinical parkinsonism & related disorders·2021

Area of Science:

  • Neurobiology
  • Cognitive Psychology
  • Psychiatry

Background:

  • Current fear-conditioning models inadequately explain memory disturbances in posttraumatic stress disorder (PTSD).
  • Episodic memory deficits surrounding traumatic events are a key clinical feature of PTSD.
  • Existing models do not fully encompass the complex memory phenomena observed in PTSD patients.

Purpose of the Study:

  • To propose a comprehensive neurobiological theory of memory processes in PTSD.
  • To integrate clinical observations with human memory research findings.
  • To offer a framework for understanding peritraumatic memory disturbances and episodic memory deficits.

Main Methods:

  • Theoretical model development based on existing human memory experiments.

Related Experiment Videos

  • Analysis of neurobiological mechanisms, focusing on amygdala and hippocampal function.
  • Integration of clinical phenomenology of PTSD with memory research.

    • Main Results:

    • The amygdala is proposed as the consolidation site for core traumatic experiences.
    • Amygdalar inhibition of hippocampal function during high emotional arousal impairs conscious memory of peritraumatic events.
    • This neurobiological mechanism explains memory disturbances characteristic of PTSD.

    Conclusions:

    • The proposed model offers a more comprehensive explanation for PTSD memory deficits than current fear-conditioning models.
    • The theory highlights the critical roles of the amygdala and hippocampus in mediating traumatic memory.
    • The model provides a basis for future experimental testing and development of targeted clinical interventions for PTSD.