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Early Intervention in Cognitive Aging with Strawberry Supplementation.

Robert Krikorian¹, Marcelle D Shidler¹, Suzanne S Summer²

¹Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH 45267, USA.

|October 28, 2023

Summary

Daily strawberry powder intake in middle-aged adults with insulin resistance improved memory and reduced depressive symptoms, suggesting a role in dementia risk reduction. Further research is needed for metabolic benefits.

Keywords:

aging anthocyanins cognition dementia risk reduction insulin resistance strawberries

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Area of Science:

Neuroscience
Public Health
Nutritional Science

Background:

Late-life dementia, including Alzheimer's disease (AD), poses a significant public health challenge with no effective treatments.
Neurodegenerative disorders develop over decades, with risk factors like insulin resistance emerging in midlife.
Dietary interventions, such as berry consumption, may influence metabolism and cognition, potentially mitigating dementia risk.

Purpose of the Study:

To investigate the effects of daily whole-fruit strawberry powder supplementation on cognitive function and metabolic measures in middle-aged adults with insulin resistance and subjective cognitive decline.

Main Methods:

A 12-week controlled trial involving overweight middle-aged men and women with insulin resistance and subjective cognitive decline.
Participants received daily whole-fruit strawberry powder, with diet records confirming adherence to berry abstinence.
Evaluated outcomes included memory interference, depressive symptoms, executive function, and metabolic markers.

Main Results:

Strawberry supplementation significantly diminished memory interference (p = 0.02) and reduced depressive symptoms (p = 0.04).
Observed cognitive benefits suggest improvements in executive ability.
No significant effects on metabolic measures were detected, potentially due to sample size, intervention duration, or anthocyanin dosage.

Conclusions:

Strawberry supplementation introduced in midlife may play a role in reducing dementia risk by improving cognitive function and mood.
Further research with extended intervention periods, larger cohorts, and varied dosages is necessary to fully elucidate the cognitive and metabolic benefits of strawberry intake in aging populations.