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Decrease of ultrasound estimated bladder weight during tamsulosin treatment in patients with benign prostatic
Dario Sironi1, Carlo Alberto Levorato, Gianfranco Deiana
1Divisione di Urologia, Ospedali Riuniti di Bergamo, Bergamo, Italy. dariosironi@virgilio.it
Summary
Ultrasound Estimated Bladder Weight (UEBW) decreased significantly in men with bladder outlet obstruction treated with tamsulosin. This suggests tamsulosin may positively impact the detrusor muscle in these patients.
Area of Science:
- Urology
- Pharmacology
Background:
- Ultrasound Estimated Bladder Weight (UEBW) is a noninvasive method to assess bladder hypertrophy.
- UEBW may aid in evaluating intravesical obstruction in male patients.
Purpose of the Study:
- To determine if tamsulosin treatment alters UEBW in male patients with bladder outlet obstruction (BOO).
Main Methods:
- An open pilot study included 32 male patients with lower urinary tract symptoms suggestive of BOO.
- Patients underwent baseline assessments including urodynamics and UEBW.
- Obstructed and equivocal patients received tamsulosin 0.4 mg daily for 6 months.
Main Results:
- A statistically significant decrease in UEBW was observed in the obstructed group, sustained for 6 months.
- Tamsulosin treatment led to a significant improvement in Qmax (maximal urine flow rate).
- UEBW showed a significant correlation with postvoid residual urine (PVR) and Abrams-Griffith number (AG).
Conclusions:
- Tamsulosin treatment resulted in a significant change in UEBW in patients with BOO.
- The observed UEBW changes suggest a potential therapeutic effect of tamsulosin on the detrusor muscle.
- Further research is warranted to confirm tamsulosin's efficacy on the detrusor muscle.