Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Warfarin fetopathy].

C Bony1, F Zyka, I Tiran-Rajaofera

  • 1Service de réanimation néonatale, CHD Félix-Guyon, 97405 Saint-Denis, La Réunion, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|August 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giant hepatic cysts: prenatal findings and uncommon postnatal outcome.

Journal of neonatal surgery·2015
Same author

Antenatal presentation of hereditary lymphedema type I.

European journal of medical genetics·2015
Same author

[Severe forms of chikungunya virus infection in a pediatric intensive care unit on Reunion Island].

Medecine tropicale : revue du Corps de sante colonial·2012
Same author

Bone-metastatic prostate carcinoma favors mesenchymal stem cell differentiation toward osteoblasts and reduces their osteoclastogenic potential.

Journal of cellular biochemistry·2011
Same author

Tibial developmental field defect in valproic acid embryopathy: Report on three cases.

American journal of medical genetics. Part A·2010
Same author

[Chikungunya in paediatrics: epidemic of 2005-2006 in Saint-Denis, Reunion Island].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2008

Warfarin embryopathy, a condition affecting fetuses exposed to vitamin K antagonists, presents with distinct developmental abnormalities. This case highlights chondrodysplasia punctata and facial dysmorphism in an infant exposed to acenocoumarol.

Area of Science:

  • Teratology
  • Developmental Biology
  • Pharmacology

Background:

  • Vitamin K antagonists, such as warfarin and acenocoumarol, are crucial for managing thromboembolic conditions during pregnancy.
  • However, fetal exposure can lead to a spectrum of congenital abnormalities known as warfarin embryopathy.
  • Understanding the risks and mechanisms is vital for informed clinical decision-making.

Observation:

  • A neonate exposed in utero to acenocoumarol presented with classic signs of warfarin embryopathy.
  • Clinical manifestations included chondrodysplasia punctata with telebrachydactyly, facial dysmorphism (nasal hypoplasia), cataracts, and bilateral pyeloureteral junction syndrome.
  • These findings underscore the teratogenic potential of vitamin K antagonists.

Findings:

  • Warfarin embryopathy affects over 6% of fetuses exposed to vitamin K antagonists in utero.

Related Experiment Videos

  • The observed anomalies represent a significant burden of disease, impacting multiple organ systems.
  • This case reinforces the diagnostic criteria for this drug-induced embryopathy.

    • Implications:

    • The case highlights the critical need for careful risk-benefit assessment when prescribing anticoagulants during pregnancy.
    • Further research into fetal vitamin K metabolism may elucidate the precise mechanisms underlying warfarin embryopathy.
    • Enhanced awareness among healthcare providers is essential for preventing and managing this condition.