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Valproate-associated dysmyelopoiesis in elderly patients
1Department of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
American Journal of Clinical Pathology
|August 7, 2002
Abstract:
Sodium valproate is widely prescribed for patients with epilepsy and psychiatric disorders. Hematologic toxic effects have been largely described in pediatric patients, and dysmyelopoiesis is reported rarely. We describe 2 elderly patients with valproate-associated dysmyelopoiesis and postulate that this particular side effect may be much more common than currently recognized. A correct diagnosis is important for acute patient anagement and for prognostication.