[Kinetics of thrombinogenesis and thrombin-fibrinogen reaction inhibition by lipoid anticoagulants]

Influence of the lipoid anticoagulant (phospholipid brain fraction) was studied as applied to thrombokinasogenesis, thrombinogenesis and on the thrombine-fibrinogene reaction with different concentrations of the substance under study and substrates of the corresponding processes. The lipoid coagulation was established to inhibit chiefly the transformation of prothrombine into thrombine and to a less extent--fibrinogene into fibrin. A graphic analysis of the inhibiton kinetics indicates that in the thrombinogenesis process the lopoid anticoagulant acts as an inhibitor which interacts with the substrate and the thrombine--fibrinogene reaction is supressed by it in the conjugate-checking manner.