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Current concepts in asthma therapy.

S R Benatar

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |October 13, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Asthma attacks are triggered by various stimuli via immunological and non-immunological pathways. Therapy targets successive sites along the trigger-to-target organ response pathway for effective asthma management.

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    Area of Science:

    • Pulmonology and Immunology

    Background:

    • Asthma attacks are triggered by diverse stimuli acting through immunological and non-immunological mechanisms.
    • Pathological hallmarks of asthma include bronchoconstriction, mucosal edema, and excessive mucus secretion in the airways.

    Purpose of the Study:

    • To outline a logical therapeutic approach for managing asthma.
    • To identify key intervention points in the asthma response pathway.

    Main Methods:

    • Review of established asthma pathophysiology.
    • Analysis of the trigger-to-target organ response pathway in asthma.

    Main Results:

    • Identification of multiple stimuli that precipitate asthma attacks.
    • Understanding the sequence of pathological changes in asthma.

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    Conclusions:

    • A structured therapeutic strategy can be developed by intervening at different stages of the asthma response.
    • Targeting successive sites in the pathway offers a logical framework for asthma treatment.