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Genetic engineering on a selective basis
1Georgetown University, Washington, DC, USA.
Princeton Journal of Bioethics
|August 9, 2002
Summary
The Human Genome Project nears a disease-free future, necessitating a precise definition of "disease" before genetic treatments are applied. This ensures only true diseases, not human variations, are targeted for genetic alteration.
Area of Science:
- Genetics
- Bioethics
- Medical Ethics
Background:
- The Human Genome Project (HGP) offers unprecedented potential for eradicating diseases.
- Advancements in genetic technology necessitate a re-evaluation of fundamental concepts in medicine.
Purpose of the Study:
- To define "disease" rigorously in the context of the Human Genome Project.
- To establish criteria for genetic alterations, distinguishing between disease and human variation.
- To consider the ethical and evolutionary implications of genetic interventions.
Main Methods:
- Conceptual analysis of the definition of "disease."
- Ethical framework development for genetic interventions.
- Review of potential evolutionary consequences of altering the human genome.
Main Results:
- A clear definition of "disease" is crucial for responsible application of genetic technologies.
- Distinguishing disease from normal human variation is essential to prevent misuse of genetic treatments.
- Establishing regulatory standards for genetic alterations is necessary.
Conclusions:
- Precise definition of "disease" is a prerequisite for ethical and effective genetic treatment.
- Careful consideration of evolutionary impacts is vital when contemplating genetic interventions.
- The HGP necessitates a robust ethical and regulatory framework for genetic medicine.