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Error-related negativity and correct response negativity in schizophrenia
Alan T Bates1, Kent A Kiehl, Kristin R Laurens
1Department of Psychiatry, University of British Columbia, BC, Vancouver, Canada.
Summary
Schizophrenia patients show reduced error-related negativity (ERN) and correct response negativity (CRN), indicating impaired self-monitoring. These brain responses are linked to specific symptom clusters in schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Schizophrenia is associated with cognitive deficits, including impaired self-monitoring.
- Previous research on error-related negativity (ERN) and correct response negativity (CRN) in schizophrenia has yielded conflicting results.
- Understanding these neural markers may offer insights into the pathophysiology of schizophrenia symptoms.
Purpose of the Study:
- To investigate ERN and CRN in schizophrenia compared to controls.
- To examine the relationship between ERN/CRN and specific symptom dimensions: disorganization, psychomotor poverty, and reality distortion.
Main Methods:
- Recorded event-related potentials (ERPs) during a go/no-go task in 21 schizophrenic and 21 control participants.
- Analyzed response-locked ERPs for commission errors (ERN) and correct responses (CRN).
- Assessed schizophrenia symptom severity using the Signs and Symptoms of Psychotic Illness (SSPI) scale.
Main Results:
- Schizophrenic participants exhibited significantly smaller ERN and CRN amplitudes than controls.
- In schizophrenic patients, ERN amplitude negatively correlated with psychomotor poverty scores.
- CRN amplitude negatively correlated with disorganization symptom scores.
Conclusions:
- Reduced ERN and CRN in schizophrenia suggest deficits in internal behavior monitoring.
- Disorganization symptoms may relate to altered response outcome comparison strategies.
- Psychomotor poverty symptoms might be associated with reduced emotional responsiveness to errors.