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Published on: April 22, 2022
5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA
John C Chaput1, Surajit Sinha, Christopher Switzer
1Department of Chemistry, University of California, Riverside, CA 92521, USA.
Abstract:
The Up.D base-pair (5-propynyl uracil.diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T.A pair; under non-enzymatic reaction conditions where the natural T.A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.
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