Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Positron emission tomography partial volume correction: estimation and algorithms.

John A D Aston1, Vincent J Cunningham, Marie-Claude Asselin

  • 1McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|August 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiscale characterization of the human claustrum from histology to MRI.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

CIVET-Chimp: An automated pipeline for MRI-based cortical surface extraction in chimpanzees.

Neuroimage. Reports·2026
Same author

Organization, fine structure, and stereotaxic maps of the human Bed nucleus of the Stria terminalis.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Comprehensive large-scale analyses reveal association between brain structure and cognitive ability during adolescence.

Communications biology·2026
Same author

Microstructural profiles of the human superficial white matter and their associations to cortical geometry and connectivity.

PLoS biology·2026
Same author

Left ventricular geometry, brain architecture, and cognition: an observational study.

European heart journal·2025
Same journal

EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Intercellular Mitochondrial Transfer in Ischemic Stroke: Emerging Roles of Microglia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Mechanical Compaction Alters Microstructural and Magnetic Resonance Imaging Properties of Acute Ischemic Stroke Clots.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Multi-modal Magnetic Resonance Imaging to Assess Cerebrovascular Function in Patients with Atrial Fibrillation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Trifluoperazine reduces infarct size, restores neurovascular coupling and improves early outcomes in experimental acute ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Advances in artificial intelligence for neuroimaging.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
See all related articles

Partial volume effects in positron emission tomography (PET) cause inaccurate radioactivity measurements. New algorithms, considering signal, noise, and tomograph characteristics, improve quantitative accuracy in PET imaging.

Area of Science:

  • Medical Imaging Physics
  • Nuclear Medicine Technology

Background:

  • Partial volume effects in Positron Emission Tomography (PET) lead to significant quantitative errors in radioactivity concentration measurements.
  • These effects, including tissue heterogeneity and regional spillover, compromise the accuracy of functional and parametric images derived from PET data.
  • Existing correction methods often do not fully account for noise distribution or integrate essential supplementary data like MRI.

Purpose of the Study:

  • To develop a comprehensive mathematical framework for Partial Volume Correction (PVC) in PET imaging.
  • To formulate new PVC algorithms that explicitly consider both signal distribution and noise characteristics.
  • To improve the quantitative accuracy of radioactivity concentration estimations in PET.

Main Methods:

Related Experiment Videos

  • Development of a mathematical framework accommodating signal and noise distributions for PVC algorithm formulation.
  • Implementation of algorithms using a weighted least squares framework for regional concentration estimation, error analysis, and inhomogeneity testing.
  • Incorporation of tensors for computationally efficient algorithms addressing tissue-fraction and spillover effects.

    • Main Results:

    • Validation of the developed framework and algorithms using both simulated and real PET data.
    • Demonstration of improved quantitative accuracy compared to existing methods by explicitly modeling noise.
    • Computationally rapid algorithms were constructed, effectively handling tissue-fraction and spillover effects.

    Conclusions:

    • The proposed mathematical framework provides a robust basis for developing advanced PVC algorithms in PET.
    • The new algorithms offer improved quantitative accuracy and computational efficiency for both static and dynamic PET imaging.
    • This work advances the reliability of quantitative analysis in PET by addressing fundamental partial volume effects.