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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
05:37

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Published on: December 22, 2017

Pathogenesis of venous thromboembolism

Cecilia Becattini1, Giancarlo Agnelli

  • 1Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Università di Perugia, Perugia, Italy.

Current Opinion in Pulmonary Medicine
|August 13, 2002
PubMed

Three factors are related with the pathogenesis of venous thrombosis: (1) blood stasis, (2) hypercoagulability, and (3) vessel damage. Local and systemic factors are implicated in blood stasis. Remarkable advances have been recently achieved regarding the understanding of the concept of hypercoagulability, with special emphasis to thrombophilic molecular abnormalities. Increased thromboembolic risk has been described in patients with antithrombin III, protein C, or protein S deficiencies as well as factor V Leiden, prothrombin mutation G20210A, or hyperhomocystinemia. Vessel wall has a remarkable role in protecting against and in promoting thrombosis. The role of inflammation on venous thrombosis is under investigation.

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