Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrated CMOS microchip system with capillary array electrophoresis.

Myong Song Joon1, Tuan Vo-Dinh

  • 1Advanced Biomedical Science and Technology Group, Life Sciences Division, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831-6101, USA.

Analytical and Bioanalytical Chemistry
|August 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninvasive whole-brain imaging of glymphatic dynamics.

Science advances·2026
Same author

Machine-learning-based tumor segmentation and classification using dynamic optical contrast imaging for thyroid cancer.

Biophotonics discovery·2026
Same author

Magneto-Plasmonics-Enhanced Colorimetric Lateral Flow Immunoassay Using Magnetic-Gold Nanostars.

ACS applied materials & interfaces·2026
Same author

Direct, Pretreatment-Free Surface-Enhanced Raman Scattering (SERS) Detection of Uric Acid in Urine Facilitated by Efficient Hydrogen Bonding-Driven Capture.

Analytical chemistry·2026
Same author

Rapid Solution-Based SERS Detection of Pesticides Using Graphene Oxide-Coated Silver-Gold Nanostars.

ACS applied nano materials·2026
Same author

Tunable and scalable production of nanostar particle platforms for diverse applications using an AI-integrated automated synthesis system.

Journal of materials science·2026

A compact complementary metal oxide semiconductor (CMOS)-capillary array electrophoresis (CAE) system was developed for DNA analysis. This miniaturized system shows great potential for high-throughput bioassays and biomedical research applications.

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Microfluidics

Background:

  • Complementary metal oxide semiconductor (CMOS) technology offers miniaturization and multiplexing capabilities.
  • Capillary array electrophoresis (CAE) is a powerful technique for DNA analysis.
  • Integrating CMOS with CAE can lead to compact, high-throughput bioassay systems.

Purpose of the Study:

  • To construct and test a miniaturized, integrated CMOS-CAE system for DNA analysis.
  • To evaluate the system's suitability for high-throughput bioassays.
  • To explore its potential for integration with other microfabricated devices.

Main Methods:

  • Simultaneous laser-beam focusing onto a capillary array and a microscope objective were used.
  • A CMOS-microchip CAE system was constructed.

Related Experiment Videos

  • DNA samples (100-bp DNA ladders and Hind III digest lambda DNA) were separated using a poly(vinylpyrrolidone) (PVP) sieving matrix.

    • Main Results:

    • A compact CMOS microchip-CAE system was successfully constructed.
    • The system demonstrated effective separation of DNA fragments.
    • The system's miniaturization and integration were validated.

    Conclusions:

    • The developed CMOS-CAE microchip system is compact and suitable for high-throughput bioassays.
    • This integrated system has significant potential for biomedical research applications.
    • Further integration with other microfabricated devices is feasible.