Related Experiment Video
Updated: Sep 30, 2026

Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
Published on: June 23, 2023
Reversed-phase HPLC of polymer additives with multiple on-line spectroscopic analysis (UV, IR, (1)H NMR and MS)
Dave Louden1, Alan Handley, Eva Lenz
1LGC, The Heath, Runcorn, Cheshire, WA7 4QD, UK.
Abstract:
The reversed-phase chromatography of a number of polymer additives has been undertaken with on-line characterisation via a combination of diode array UV, (1)H NMR, IR spectroscopy and mass spectrometry. This combination of spectrometers enabled the on-flow collection of full UV, (1)H NMR, IR and mass spectra for a range of common polymer additives in amounts ranging from ca. 230 to 900 micro g on-column. The practical difficulties associated with multiple hyphenation and potential future developments are discussed.
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