Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A quick and simple method for detecting subjects with abnormal genetic background in case-control samples.

D Curtis1, B V North, H M D Gurling

  • 1Joint Academic Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine, and Dentistry, UK. dcurtis@hgmp.mrc.ac.uk

Annals of Human Genetics
|August 14, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic bases of schizophrenia phenotypes: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2026
Same author

Role of microRNAs in sight-threatening diabetic retinopathy in Chinese patients: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Prevalence, time trends, and correlates of major depressive episode and other psychiatric conditions among young people amid major social unrest and COVID-19 in Hong Kong: a representative epidemiological study from 2019 to 2022.

The Lancet regional health. Western Pacific·2023
Same author

Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder.

Psychopharmacology·2022
Same author

Healthcare-associated infections and the prescribing of antibiotics in hospitalized patients of the Caribbean Community (CARICOM) states: a mixed-methods systematic review.

The Journal of hospital infection·2021
Same author

Thermal Imaging of Root Caries In Vivo.

Journal of dental research·2020

Genetically homogeneous case-control samples are crucial for accurate genetic studies. A new, straightforward test identifies and removes subjects with different genetic backgrounds, improving study reliability.

Area of Science:

  • Population Genetics
  • Genetic Epidemiology

Background:

  • Case-control studies require genetically homogeneous populations to prevent false positives and increase the power to detect disease mutations.
  • Simple allele frequency comparisons between cases and controls can miss subjects from divergent genetic backgrounds.
  • Existing multilocus tests for identifying such subjects are often complex and cumbersome.

Purpose of the Study:

  • To develop a straightforward and efficient method for identifying subjects with divergent genetic backgrounds within case-control samples.
  • To improve the reliability and power of genetic association studies.

Main Methods:

  • Implementation of a straightforward test using the CHECKHET program.
  • Utilizing a measure of genetic difference and permutation procedures.

Related Experiment Videos

  • Analysis of genotypes from multiple unlinked markers to identify outlier subjects.

    • Main Results:

    • The developed test performs well on simulated data.
    • The method successfully identified two potentially abnormal subjects in a real case-control sample.
    • The approach is rapid and less complex than previously described methods.

    Conclusions:

    • Routine application of this straightforward test is recommended for case-control samples.
    • Identifying and removing subjects with different genetic backgrounds enhances the validity of genetic association studies.
    • This method improves the detection of disease mutations and markers in linkage disequilibrium.