Differential effects of chronic spinal hemisection on somatic and visceral inputs to caudal brainstem

The medullary reticular formation (MRF) receives convergent inputs from multiple somatic and pelvic/visceral territories. The effects of chronic 30-day lateral hemisections at T8 on the responses of single MRF neurons to noxious mechanical stimulation of both hindpaws was examined in urethane-anesthetized male rats. Neuronal responses on both sides of the MRF to pinching of the hindpaw on the side opposite the lesion (intact-side) were found either to be completely absent or if present, weak (i.e. hindpaw was hyposensitive). The presence or absence of intact-side responses appeared to be dependent on the lesion extent. In contrast, bilateral MRF responses to pinching the lesion-side hindpaw were present; however, responses were greater in magnitude (lower thresholds) relative to surgical sham controls suggesting hypersensitivity. Responses to lesion-side hindpaw stimulation on both sides of the MRF indicated that whereas the ascending projections are primarily crossed below the level of lesion, they are both crossed and uncrossed above. These findings are in contrast with our previous data on ascending projections from the bilaterally organized male urogenital tract. The results presented for the hindpaws correlate with clinical observations of patients with similar incomplete spinal cord injuries (Brown-Séquard syndrome).