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Related Experiment Videos

Formulation factors in preparing BTM-chitosan microspheres by spray drying method.

Y Huang1, M Yeh, C Chiang

  • 1Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, ROC.

International Journal of Pharmaceutics
|August 15, 2002
PubMed
Summary

Chitosan microspheres modified with gelatin were developed for pulmonary drug delivery. Optimized formulations showed sustained release of Betamethasone disodium phosphate for 12 hours.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Chitosan (CTS) microspheres are promising for drug delivery.
  • Modifying microspheres can enhance their properties for specific applications like pulmonary delivery.

Purpose of the Study:

  • To prepare and characterize Chitosan (CTS) microspheres using gelatin and a block copolymer.
  • To evaluate the impact of gelatin concentration on microsphere properties and drug release.
  • To optimize Betamethasone disodium phosphate (BTM)-loaded microspheres for pulmonary delivery.

Main Methods:

  • Spray drying method for microsphere preparation.
  • Scanning electron microscopy (SEM) for surface morphology analysis.
  • Microelectrophoresis for surface charge determination.

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  • In vitro drug release studies.

    • Main Results:

    • Gelatin concentration significantly influenced microsphere shape, size, and surface morphology.
    • BTM-loaded microspheres exhibited high drug stability (>99%), high entrapment efficiency (~95%), and a positive surface charge (~37.5 mV).
    • Microspheres with a gelatin/CTS ratio of 0.4-0.6 (w/w) demonstrated a sustained drug release profile over 12 hours.

    Conclusions:

    • Gelatin and block copolymer effectively modified Chitosan microspheres.
    • Formulation parameters, particularly gelatin content, are crucial for optimizing BTM-loaded microspheres for pulmonary applications.
    • The developed microspheres show potential for controlled pulmonary drug delivery.