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Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
Published on: August 2, 2012
Influence of chemical structure of amphiphilic beta-cyclodextrins on their ability to form stable nanoparticles
Annabelle Gèze1, Soad Aous, Isabelle Baussanne
1Département de Pharmacochimie Moléculaire, UMR CNRS 5063, UFR Pharmacie, Université Joseph Fourier-Grenoble I, 5 av. de Verdun, F 38243 Cedex, Meylan, France.
Abstract:
The aim of the study was to establish a correlation between the chemical structure of amphiphilic beta-cyclodextrins (beta-CDa) and their ability to form stable nanospheres. Amphiphilic derivatives were obtained according to an optimized well-known three-step synthesis. The selective acylation of the secondary face of beta-CD being well controlled, several beta-CDa presenting different substitution degree were synthesized. The self-organization properties of the derivatives were evaluated. The peracylated beta-CD, i.e. bearing 14 alkyl chains on the secondary hydroxyl groups, does not yield stable nanosphere suspension, even in the presence of a non ionic surfactant in the aqueous phase. However, the presence of partially acylated derivatives within the beta-CDa allows self-assembly into stable nanosphere suspension.
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