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DiffTool: building, visualizing and querying protein clusters.

Farid Chetouani¹, Philippe Glaser, Frank Kunst

¹Laboratoire Génomique des Microorganismes Pathogénes, Institut Pasteur, Département de Biologie Moléculaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. fchetou@infobiogen.fr

Bioinformatics (Oxford, England)

|August 15, 2002

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Terms & Conditions of Use

DiffTool builds and visualizes protein clusters from sequence data, aiding in the identification of protein families and specific genomic features. This resource offers tools for clustering, visualization, and subtractive genome analysis.

Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

Protein clustering is essential for understanding protein families and functions.
Genomic analysis requires efficient tools for sequence similarity comparisons.
Existing resources may lack integrated visualization and subtractive analysis capabilities.

Purpose of the Study:

To introduce DiffTool, a novel resource for building and visualizing protein clusters.
To provide a tool for constructing protein families based on sequence similarity.
To enable subtractive genome analysis for identifying specific protein families.

Main Methods:

Utilizing a clustering tool to group proteins by sequence similarity.
Developing a web interface for querying and visualizing protein clusters.

Related Experiment Videos

Implementing a subtractive genome analysis module for targeted family selection.

Main Results:

DiffTool successfully builds and visualizes protein clusters from sequence databases.
The resource provides access to sequences, multiple alignments, and phylogenetic trees for each cluster.
Subtractive analysis enables the identification of genome-specific protein families.

Conclusions:

DiffTool offers a comprehensive solution for protein family analysis and visualization.
The resource facilitates comparative genomics and the study of protein evolution.
DiffTool is available as a queryable database and freely available Perl sources for non-profit use.