Related Experiment Videos
[The advances in immunological research on xenotransplantation]
1Laboratory of Transplant Engineering & Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China 610041. feng31@sohu.com
Objective:
To investigate the mechanism of xenotransplantation rejection and the interaction between the immunocytes.
Methods:
This review concluded the research achievements and new advances in xenotransplantation based on the relevant experimental data.
Results:
Transgenic pig technology and novel immunosuppressants were applied to suppress hyperacute rejection and acute vascular rejection respectively. Modulation of T cell and antigen presenting cells and induction of tolerance were taken for the prevention of acute cellular rejection.
Conclusion:
In general, the technology of transgenic pig is relatively mature and effective. The mechanism and prevention of acute vascular rejection and acute cellular rejection should be further investigated.