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Related Experiment Videos

Familial presacral teratomas.

K W Ashcraft, T M Holder, D J Harris

    Birth Defects Original Article Series
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study describes a rare presacral teratoma complex linked to sacral deformities, occurring in multiple families. The condition appears to be inherited in a dominant pattern, with varied clinical manifestations.

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    Area of Science:

    • Oncology
    • Genetics
    • Pediatric Surgery

    Background:

    • A rare tumor complex involving presacral teratoma and sacral deformity is presented.
    • This complex exhibits variable clinical manifestations, including recurrent abscesses, rectal stenosis, and skin dimples.

    Purpose of the Study:

    • To describe a unique tumor complex characterized by presacral teratoma and sacral deformity.
    • To investigate the familial occurrence and inheritance pattern of this condition.

    Main Methods:

    • Case series description of 6 kindreds with the tumor complex.
    • Clinical and pathological review of 19 resected tumors.

    Main Results:

    • The tumor complex is associated with sacral deformity and other anomalies like urinary tract defects.

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  • Most resected tumors (18/19) were benign, with only one malignant case.
  • Two benign tumors recurred post-resection.
  • The condition demonstrates a pattern consistent with dominant inheritance.

    • Conclusions:

    • This presacral teratoma complex is distinct from typical sacrococcygeal teratomas.
    • The condition has a familial occurrence and appears to be inherited as a dominant trait.
    • While predominantly benign, recurrence is possible, necessitating careful follow-up.