New glycosyl-(carboxamide)-1,2,3-triazole-N-nucleosides: synthesis and antitumor activity
Najim A Al-Masoud1, Yaseen A Al-Soud
1Faculty of Chemistry, University of Konstanz, Germany. Najim.Al-Masoudi@uni-konstanz.de
Nucleosides, Nucleotides & Nucleic Acids
|August 17, 2002
Abstract:
A series of potential bioactive compounds, 1-glucopyranosyl- 1,2,3-triazole-4,5-dimethylcarboxylate, 1-glucopyranosyl-1,2,3-triazole-4,5-N-dicarboxamide,-dialkyl-dicarboxamide-N-nucleosides and 6-amino-4H-1-(beta-D-glucopyranosyl)-8-hydroxy-1,2.3-triazolo[4,5-e][1,3]-diazepin-4-one, were synthesized. Primary activity screening of the novel nucleosides showed poor or no anticancer activity against breast, lung and CNS tumors.
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