[A pharmacologic analysis of several adrenomimetic effects of serotonin]

Contractions of the isolated rat vas deferens in response to the addition of serotonin could be explained by the release of catecholamines from the nerve endings. As shown by the use of D-, M- and T-antagonists of serotonin (LSD-25, indocarb, typindole), symatholytic--bretilium, alpha-adrenolytic--droperidol and imipramine, this effect was not associated with the direct activation of serotonin- and adrenoreactive receptors.