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Synthesis of functionalized 1,5-cyclooctadienes by LICKOR metalation
Jefferson D Revell1, A Ganesan
1Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.
The Journal of Organic Chemistry
|August 17, 2002
Abstract:
1,5-Cyclooctadiene was lithiated under LICKOR superbase conditions followed by reaction with alkyl halides or ethylene oxide to yield 3-substituted 1,5-cyclooctadienes in high yield and purity. This procedure is suitable for preparation of 1,5-cyclooctadienes carrying pendant functional groups for immobilization on solid-phase resins.