Related Experiment Videos
Dihydroquinolines as novel n-NOS inhibitors
Stefan Jaroch1, Peter Hölscher, Hartmut Rehwinkel
1Department of Medicinal Chemistry, Corporate Research, Schering AG, D-13342-Berlin, Germany. stefan.jaroch@schering.de
Bioorganic & Medicinal Chemistry Letters
|August 17, 2002
Abstract:
Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring.