Discovery and development of antidepressants: a perspective from a pharmaceutical discovery company

Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.

Molecular psychiatry·2022

The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain.

Molecular psychiatry·2022

Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.

Nature communications·2022

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.

iScience·2021

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation.

Scientific reports·2020

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.

Science translational medicine·2020

Comparisons of the structure and function of higher cortical circuits in marmosets and macaques: Models for mental health disorders.

Biological psychiatry·2026

Dexamphetamine-induced striatal hyperdopaminergia attenuates reward-related neural activation: A11C-PHNO PET-fMRI study.

Biological psychiatry·2026

Mechanistic computational models of cognition across scales and species.

Biological psychiatry·2026

Neurophysiological Signatures of Negative Symptom Improvement After High-Definition Transcranial Direct Current Stimulation: A Transcranial Magnetic Stimulation-Electroencephalography Study.

Biological psychiatry·2026

Differential Effects of Illness and Antipsychotics on Cortical Thinning in First-Episode Psychosis: A Randomized, Placebo-Controlled Magnetic Resonance Imaging Study.

Biological psychiatry·2026

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.

Biological psychiatry·2026

Intranasal delivery of sertraline hydrochloride enhanced brain concentration and antidepressant activity: A comparative pharmacokinetic and pharmacodynamic study.

Journal of pharmaceutical sciences·2026

The Evolving Role of Peripheral Nerve Stimulation in Postoperative Analgesia and Recovery.

Current pain and headache reports·2026

Allosteric Crosstalk between Inhibitor Binding Sites Drives Enhanced Islatravir Susceptibility in F227C HIV-1 Reverse Transcriptase.

ACS infectious diseases·2026

Insight Into the Recent Advancements in Thiazolidinedione Derivatives as PPAR-γ Agonists for the Treatment of Type 2 Diabetes.

Mini reviews in medicinal chemistry·2026

Neuromodulation therapies in the management of tardive dyskinesia: A scoping review.

Indian journal of psychiatry·2026

Combining the optimization of the CT examination process with a vial sharing strategy for contrast agents: an economical and practical method for hospitals.

BMC health services research·2026

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Discovery and development of antidepressants: a perspective from a pharmaceutical discovery company

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Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.

The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain.

Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation.

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.

Comparisons of the structure and function of higher cortical circuits in marmosets and macaques: Models for mental health disorders.

Dexamphetamine-induced striatal hyperdopaminergia attenuates reward-related neural activation: A11C-PHNO PET-fMRI study.

Mechanistic computational models of cognition across scales and species.

Neurophysiological Signatures of Negative Symptom Improvement After High-Definition Transcranial Direct Current Stimulation: A Transcranial Magnetic Stimulation-Electroencephalography Study.

Differential Effects of Illness and Antipsychotics on Cortical Thinning in First-Episode Psychosis: A Randomized, Placebo-Controlled Magnetic Resonance Imaging Study.

Diversity of Layer 3 Pyramidal Neuron Properties Across Areas of the Primate Neocortex.

Intranasal delivery of sertraline hydrochloride enhanced brain concentration and antidepressant activity: A comparative pharmacokinetic and pharmacodynamic study.

The Evolving Role of Peripheral Nerve Stimulation in Postoperative Analgesia and Recovery.

Allosteric Crosstalk between Inhibitor Binding Sites Drives Enhanced Islatravir Susceptibility in F227C HIV-1 Reverse Transcriptase.

Insight Into the Recent Advancements in Thiazolidinedione Derivatives as PPAR-γ Agonists for the Treatment of Type 2 Diabetes.

Neuromodulation therapies in the management of tardive dyskinesia: A scoping review.

Combining the optimization of the CT examination process with a vial sharing strategy for contrast agents: an economical and practical method for hospitals.

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Discovery and development of antidepressants: a perspective from a pharmaceutical discovery company

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