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Immunotherapy as a means to induce transplantation tolerance
Scott H Adler1, Laurence A Turka
1University of Pennsylvania Department of Medicine, Renal-Electrolyte and Hypertension Division, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA. shadler@mail.med.upenn.edu
Current Opinion in Immunology
|August 17, 2002
Abstract:
There have been several recent advances in the use of immunotherapy to induce transplantation tolerance. These include newer and safer protocols to create hematopoietic chimerism, the development of more-powerful T cell depleting antibodies, the identification of additional costimlulatory pathways as molecular targets and the identification of a role for suppressor cells in transplant tolerance.