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Modulation of synaptic delay during synaptic plasticity.

Jen-Wei Lin1, Donald S Faber

  • 1Dept of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA. jenwelin@bu.edu

Trends in Neurosciences
|August 17, 2002
PubMed
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Investigating synaptic delay reveals that the time it takes for neurotransmitter release is not fixed. This synaptic delay is modifiable, suggesting direct modulation of transmitter secretion during short-term synaptic plasticity.

Area of Science:

  • Neuroscience
  • Synaptic Transmission
  • Cellular Electrophysiology

Background:

  • Information on neurotransmitter release is typically inferred indirectly from postsynaptic responses.
  • Electrophysiological parameters like amplitude and latency (synaptic delay) are traditionally used.
  • Synaptic delay reflects the kinetics of events leading to neurotransmitter release.

Purpose of the Study:

  • To investigate the modifiability of synaptic delay.
  • To explore the implications of synaptic delay changes for understanding short-term synaptic plasticity.
  • To evaluate models of short-term synaptic plasticity based on synaptic delay variations.

Main Methods:

  • Analysis of postsynaptic responses to infer presynaptic activity.
  • Measurement and characterization of synaptic delay distributions.

Related Experiment Videos

  • Evaluation of existing models of short-term synaptic plasticity.

    • Main Results:

    • Synaptic delay is not invariant and can be modified.
    • Observed changes in synaptic delay correlate with short-term synaptic plasticity.
    • This suggests direct modulation of the transmitter secretion step.

    Conclusions:

    • Synaptic delay is a dynamic parameter reflecting plasticity.
    • Direct modulation of transmitter secretion is a plausible mechanism.
    • Models of short-term synaptic plasticity need to account for synaptic delay dynamics.