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Updated: Sep 29, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
[Therapeutic monitoring of cyclosporine A]
I Komzáková1, K Safarcík, H Brozmanová
1Ustav klinické farmakologie FNsP a Zdravotnĕ sociální fakulta Ostravské Univerzity, Ostrava. ilona.komzakova@fnspo.cz
Abstract:
Cyclosporine A (CyA) is a drug with a specific influence on the immune system and it is used both to prevent tissue rejection of transplanted organs and to treat autoimmune diseases. The properties, metabolism, and methods of therapeutic drug monitoring (TDM) in patients under immunosuppressive therapy are described. TDM of CyA reflects the clinical condition of the patient during immunosuppression and may include pharmacokinetic and pharmacodynamic data obtained either from measuring CyA levels in blood, or from determining some other parameters, which are modulated by CyA (II-2). Although TDM is mainly based on analyzing trough levels of CyA, the determination of the whole biological exposition calculated as AUC enables better correlation with the clinical state of patients. Pharmacodynamic parameters have not been measured routinely yet.
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