Related Experiment Videos
Blood thiols and malondialdehyde levels in psoriasis
Vineet Relhan1, Sunil K Gupta, Surabhi Dayal
1Department of Skin, V.D. and Leprosy, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Haryana, India.
The Journal of Dermatology
|August 20, 2002
Summary
Oxidative stress markers are altered in psoriasis. Total blood thiols were lower and plasma malondialdehyde (MDA) was higher in active psoriasis patients, suggesting their role in the disease.
Area of Science:
- Biochemistry
- Dermatology
- Oxidative Stress Research
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Oxidative stress is implicated in various diseases.
- Antioxidant defence systems and lipid peroxidation are key indicators of oxidative stress.
Purpose of the Study:
- To investigate the levels of total blood thiols and plasma malondialdehyde (MDA) in patients with psoriasis.
- To compare these oxidative stress markers between psoriatic patients in acute and remission phases and healthy controls.
Main Methods:
- Studied 40 patients with psoriasis and 40 healthy controls.
- Measured total blood thiol levels, an indicator of antioxidant capacity.
- Assessed plasma malondialdehyde (MDA) levels, a marker of lipid peroxidation.
Main Results:
- Total blood thiols were significantly lower in psoriatic patients during the acute phase compared to controls.
- Total blood thiol levels did not differ significantly between psoriatic patients in remission and controls.
- Plasma MDA levels were significantly elevated in psoriatic patients during the acute phase compared to controls and those in remission.
Conclusions:
- Oxidative stress plays a significant role in the pathogenesis of psoriasis.
- The study highlights the potential of targeting oxidative stress pathways in psoriasis treatment.