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Quantitative cardiovascular autonomic function study in Fisher syndrome.

R-K Lyu1, L-M Tang, W-C Hsu

  • 1Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan. lyu5172@adm.cgmh.org.tw

Journal of Neurology, Neurosurgery, and Psychiatry
|August 20, 2002
PubMed
Summary

Fisher syndrome (FS) patients often show autonomic dysfunction, detectable by quantitative tests, not clinical signs. While both parasympathetic and sympathetic functions are affected, parasympathetic nerve fibers are less vulnerable in FS.

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Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Fisher syndrome (FS) is a rare neurological disorder.
  • Autonomic dysfunction can occur in FS, but its clinical manifestation is not always apparent.

Purpose of the Study:

  • To quantitatively assess cardiovascular autonomic function in patients with Fisher syndrome longitudinally.
  • To compare the sensitivity of clinical signs versus quantitative tests in detecting autonomic dysfunction in FS.

Main Methods:

  • Longitudinal quantitative cardiovascular autonomic function tests were performed on nine FS patients.
  • Tests included Valsalva ratio, RR interval variation (parasympathetic function), and blood pressure responses to handgrip and standing (sympathetic function).

Main Results:

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  • Up to 83% of FS patients exhibited autonomic function abnormalities, despite lacking clinical signs.
  • Autonomic function generally improved between 4-12 weeks post-onset.
  • Both parasympathetic and sympathetic functions were affected, with parasympathetic fibers showing less vulnerability.

    • Conclusions:

    • Quantitative autonomic function testing is superior to bedside clinical signs for detecting autonomic abnormalities in FS.
    • Autonomic dysfunction in FS is often transient, with a tendency towards recovery.
    • Fisher syndrome involves both parasympathetic and sympathetic systems, with differential vulnerability of nerve fibers.