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Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
Published on: March 13, 2016
Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies
Jorge Sánchez-Quesada1, Markus P Isler, M Reza Ghadiri
1Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
Abstract:
A selective heteromeric supramolecular assembly process is devised to create functional single channels of altered ion conductance, charge selectivity, and rectification. The hollow transmembrane tubular structure produced spontaneously from the self-assembly of cyclic-d,l-alpha-peptides in lipid bilayers is modified by designer cyclic peptide "cap" subunits that bind site-selectively at the mouth of the channel assembly.
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