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Updated: Feb 11, 2026

Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents
Published on: August 7, 2013
A Synthetic Pore-Mediated Transmembrane Transport of Glutamic Acid
Jorge Sánchez-Quesada1, Hui Sun Kim1, M Reza Ghadiri1
1Departments of Chemistry and Molecular Biology, and The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Fax: (+1) 858-784-2798.
Abstract:
Transported to the other side: Cyclic D,L-α-peptides self-assemble in lipid bilayers into transmembrane ion channels that may allow efficient transport of glutamic acid. The molecular transport is size/shape selective, as evidenced by the high transport rates observed with cyclodecapeptide-based transmembrane pores but not with the smaller cyclooctapeptide analogue.
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