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[Clear cell sarcoma of the kidney: 3 case reports]
Abdellatif Benchekroun1, Mohamed Zannoud, Haj Ahmed el Alj
1Clinique Urologique A, Hôpital Avicenne, Rabat-Salé, Maroc. benchek@mtas.com
Summary
Clear cell sarcoma of the kidney (CCSK) is rare in adults. One patient treated with chemotherapy showed no recurrence, while two untreated patients experienced recurrence and metastasis, highlighting potential treatment benefits.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Clear cell sarcoma of the kidney (CCSK) is a rare and highly malignant pediatric neoplasm.
- Adult occurrence of CCSK is exceptionally uncommon, typically documented in isolated case reports.
Observation:
- This study presents three adult cases of CCSK (one male, two female, ages 23-65).
- All patients underwent radical nephrectomy with hilar lymph node dissection.
- One patient received six cycles of combination chemotherapy (cisplatin and doxorubicin).
Findings:
- The patient who received chemotherapy showed no evidence of tumor on CT scans four years post-treatment.
- One untreated patient developed psoas recurrence within three months, followed by retroperitoneal, liver, and spleen metastasis, leading to death seven months later.
- The second untreated patient died seven months after nephrectomy due to disease progression.
Implications:
- The optimal treatment strategy for adult clear cell sarcoma of the kidney remains undetermined.
- Findings suggest that combination chemotherapy may offer a survival benefit in adult CCSK.
- Further research is needed to establish effective treatment protocols for this rare malignancy.