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Related Experiment Videos

Mirtazapine-induced hepatotoxicity.

Chee-Kin Hui1, Man-Fung Yuen, Wai-Man Wong

  • 1Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

Journal of Clinical Gastroenterology
|August 23, 2002
PubMed
Summary

Mirtazapine, an antidepressant, can cause severe liver damage and prolonged jaundice in some patients. These cases highlight the importance of monitoring liver function during mirtazapine treatment for depression.

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Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Psychiatry

Background:

  • Mirtazapine is a widely prescribed tetracyclic antidepressant used for treating major depressive disorder.
  • Hepatotoxicity is a known potential adverse effect of various medications, but specific reports on mirtazapine-induced liver injury are limited.

Observation:

  • Two female patients developed severe hepatotoxicity, characterized by prolonged jaundice, during treatment with mirtazapine for depression.
  • In the first case, symptoms appeared after 3 years of mirtazapine use and resolved upon drug discontinuation.
  • The second patient experienced prolonged jaundice, with recovery taking three months after withdrawing mirtazapine.

Findings:

  • These cases represent the first reported instances of mirtazapine-induced prolonged jaundice.

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  • The exact mechanism underlying mirtazapine's hepatotoxicity remains undetermined.
  • Both patients exhibited significant derangement in liver function tests indicative of drug-induced liver injury.

    • Implications:

    • Clinicians should consider mirtazapine as a potential cause of hepatotoxicity, especially in cases of unexplained prolonged jaundice.
    • Monitoring liver function may be warranted in patients on long-term mirtazapine therapy.
    • Further research is needed to elucidate the pathophysiology of mirtazapine-induced liver injury and identify risk factors.