Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive dysfunction in neuropsychiatric systemic lupus erythematosus.

Melanie J Harrison1, Lisa D Ravdin

  • 1Division of Rheumatology, Weill Medical College of Cornell University, New York, New York 10021, USA. harrisonm@hss.edu

Current Opinion in Rheumatology
|August 23, 2002
PubMed
Summary

Systemic lupus erythematosus (SLE) often causes cognitive dysfunction. Research is refining understanding of its varied causes, patterns, and detection methods in patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standard-of-care idecabtagene vicleucel for relapsed/refractory multiple myeloma.

Blood·2025
Same author

Problem Adaptation Therapy for Older Adults with Chronic Pain and Negative Emotions in Primary Care (PATH-Pain): A Randomized Clinical Trial.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2025
Same author

Correlates of neurocognitive performance in older adults with chronic pain and negative emotions: baseline data from the problem adaptation therapy for pain (PATH-pain) randomized controlled trial.

Frontiers in pain research (Lausanne, Switzerland)·2024
Same author

Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.

Journal of autoimmunity·2020
Same author

Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits.

International psychogeriatrics·2020
Same author

Neurocognition and Cerebral Lesion Burden in High-Risk Patients Before Undergoing Transcatheter Aortic Valve Replacement: Insights From the SENTINEL Trial.

JACC. Cardiovascular interventions·2018

Area of Science:

  • Rheumatology
  • Neuroscience
  • Psychiatry

Background:

  • Neuropsychiatric syndromes are common in systemic lupus erythematosus (SLE), presenting diverse etiologies and clinical manifestations.
  • Cognitive dysfunction is a prevalent manifestation within SLE neuropsychiatric syndromes, characterized by significant heterogeneity.
  • Previous research focused on identifying and describing SLE-associated cognitive dysfunction and its common correlates.

Purpose of the Study:

  • To elucidate the relative strengths of various risk associations for cognitive impairment in SLE.
  • To characterize patterns of cognitive abnormalities in SLE, both cross-sectionally and longitudinally.
  • To explore novel functional and biological methods for identifying cognitive impairment in SLE patients.

Main Methods:

Related Experiment Videos

  • Review and synthesis of recent research on SLE-associated cognitive dysfunction.
  • Analysis of cross-sectional and longitudinal data on cognitive patterns.
  • Investigation of novel biomarkers and functional assessments for cognitive impairment.

    • Main Results:

    • Established risk factors include neuropsychiatric disease history, corticosteroid use, disease activity, emotional distress, and antiphospholipid antibodies.
    • Detailed characterization of cognitive deficits and their evolution over the clinical course of SLE.
    • Identification of promising new avenues for detecting and monitoring cognitive impairment.

    Conclusions:

    • Cognitive dysfunction in SLE is multifactorial and requires nuanced understanding.
    • Ongoing research is advancing the identification and characterization of cognitive impairment in SLE.
    • Novel diagnostic and monitoring strategies are emerging for SLE-related cognitive issues.