Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Fluoroquinolones in children].

D Gendrel1

  • 1Hôpital Saint Vincent de Paul, 82 Av Denfert-Rochereau, 75014 Paris, France. dominique.gendrel@svp.ap-hop-paris.fr

Medecine Tropicale : Revue Du Corps De Sante Colonial
|August 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial treatment of diarrhea/acute gastroenteritis in children.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2018
Same author

Five-Day Spiramycin vs Seven-Day Penicillin V in the Treatment of Streptococcal Tonsillitis in Children.

Clinical drug investigation·2016
Same author

Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

[Safety of oral ivermectin in children].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2015
Same author

Markers of a recent bocavirus infection in children with Kawasaki disease: "a year prospective study".

Pathologie-biologie·2014
Same author

[Treatment of scabies: from recommendations to pediatric practice].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2014

Fluoroquinolones are recommended for pediatric cystic fibrosis patients but carry risks like arthrotoxicity. Their use should be limited to severe infections with no alternatives, balancing benefits against risks to combat bacterial resistance.

Area of Science:

  • Pediatric infectious diseases
  • Pharmacology
  • Antimicrobial stewardship

Background:

  • Fluoroquinolones are rarely recommended for children, primarily for pyocyanic infections in cystic fibrosis.
  • Arthrotoxicity is a key contraindication, though use is considered for serious infections lacking alternatives.

Purpose of the Study:

  • To review current and potential pediatric indications for fluoroquinolones.
  • To discuss safety concerns, particularly arthrotoxicity, in pediatric populations.
  • To emphasize restricted use and antimicrobial stewardship.

Main Methods:

  • Literature review of fluoroquinolone use in pediatric populations.
  • Analysis of contraindications and potential indications.
  • Discussion of safety data and reporting challenges.

Related Experiment Videos

Main Results:

  • Current pediatric use is limited to specific indications like cystic fibrosis.
  • Potential uses include multidrug-resistant infections and complicated UTIs.
  • Arthrotoxicity risk is similar or slightly higher than in adults; underreporting of adverse events is an issue.

Conclusions:

  • Fluoroquinolones should remain second or third-line agents for severe pediatric infections when no other options exist.
  • Restricting use is crucial to minimize risks and slow the emergence of resistant bacteria.
  • Newer quinolones may offer alternatives for specific conditions like resistant pneumococcal meningitis.