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Relationship between thyroid autoimmunity and Yersinia enterocolitica antibodies
Demet Corapçioğlu1, Vedia Tonyukuk, Mehmet Kiyan
1Department of Endocrinology and Metabolic Diseases, Ankara University School of Medicine, Ankara, Turkey. corapcioglu@superonline.com
Thyroid : Official Journal of the American Thyroid Association
|August 24, 2002
Summary
Subclinical Yersinia enterocolitica infection may trigger autoimmune thyroid disease (AITD). This study found higher Y. enterocolitica antibodies in Graves
Area of Science:
- Endocrinology
- Immunology
- Microbiology
Background:
- Subclinical Yersinia enterocolitica infection is a potential factor in autoimmune thyroid disease (AITD).
- Investigating the link between Y. enterocolitica antibodies and thyroid autoantibodies is crucial for understanding AITD etiology.
Purpose of the Study:
- To examine the relationship between thyroid autoantibodies and antibodies against Yersinia enterocolitica serotypes.
- To determine the prevalence of Y. enterocolitica antibodies in patients with Graves' disease (GD), Hashimoto's thyroiditis (HT), and nontoxic diffuse goiter (NTDG).
Main Methods:
- Blood samples from 215 subjects (65 GD, 57 HT, 53 NTDG, 40 controls) were analyzed.
- Measurements included thyroid receptor antibodies (TRAb) and antibodies against Y. enterocolitica serotypes O:3, O:5, O:8, and O:9.
Main Results:
- Y. enterocolitica antibody positivity was highest in GD (53.8% for O:3, 44.6% for O:8) and HT.
- TRAb levels were significantly higher in GD patients compared to other groups.
- A weak linear correlation was observed between TRAb levels and Y. enterocolitica antibody titers.
Conclusions:
- Yersinia enterocolitica infection may contribute to the development of Graves' disease in the Turkish population.
- Further research is warranted to elucidate the specific mechanisms linking Y. enterocolitica to AITD.