Reliable glucose monitoring through the use of microsystem technology

A continuous amperometric glucose monitoring system is presented. All analytically relevant units are integrated on a microchip (microreactor, control electrode, glucose oxidase based sensor electrode, reference electrode, counter electrode). The scavenging electrochemical microreactor pre-oxidises all interfering compounds enabling a reliable glucose determination. The reliability of the microreactor is demonstrated with the most important antioxidants, ascorbic and uric acids. The glucose sensor system operates at volumetric flow rates of common body interfaces (e.g. microdialysis, microperfusion).