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Related Experiment Videos

Pulmonary diffusing capacity in chronic dialysis patients.

J A Herrero1, J L Alvarez-Sala, F Coronel

  • 1Department of Nephrology, Hospital Clínico San Carlos, Madrid, Spain. jaherrero@sensefro.org

Respiratory Medicine
|August 27, 2002
PubMed
Summary

Long-term hemodialysis using bioincompatible membranes can cause reduced pulmonary diffusing capacity. This study found significant decreases in carbon monoxide transfer factor (TLCO) and KCO in patients on long-term dialysis, suggesting chronic pulmonary fibrosis.

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Area of Science:

  • Nephrology
  • Pulmonology
  • Biomaterials Science

Background:

  • End-stage renal disease (ESRD) patients on hemodialysis face risks from bioincompatible membranes.
  • Acute effects on lung microcirculation can lead to pulmonary fibrosis and diffusion defects with long-term dialysis.

Purpose of the Study:

  • To investigate chronic pulmonary alterations in hemodialysis patients.
  • To compare lung function in patients before dialysis, short-term dialysis, and long-term dialysis.

Main Methods:

  • Studied 43 patients in three groups: pre-dialysis, <12 months dialysis, >5 years dialysis.
  • Utilized first-use bioincompatible cellulosic dialysis membranes.
  • Measured lung function parameters including FVC, FEV1, TLC, RV, TLCO, VA, KCO, and arterial blood gases.

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Main Results:

  • Long-term hemodialysis patients (>5 years) showed significantly lower TLCO and KCO.
  • 75% of long-term dialysis patients had reduced TLCO or KCO compared to 17% pre-dialysis and 10% short-term.

Conclusions:

  • Long-term hemodialysis with bioincompatible membranes is associated with reduced pulmonary diffusing capacity.
  • Chronic pulmonary fibrosis is a likely cause of these observed pulmonary function changes.