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Memapsin 2 (beta-secretase) as a therapeutic target
L Hong1, R T Turner, G Koelsch
1Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Biochemical Society Transactions
|August 28, 2002
Abstract:
As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease. As such, memapsin 2 is an excellent target of inhibitor drugs for the treatment of this disease. Here we describe the tools for memapsin 2 inhibitor design that have been developed and results from the structure-based inhibitor design. Strategy for the design of memapsin 2 inhibitors with pharmaceutical potential is also discussed.