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A total synthesis of phomactin A
William P D Goldring1, Gerald Pattenden
1School of Chemistry, University of Nottingham, University Park, Nottingham, UK NG7 2RD.
Chemical Communications (Cambridge, England)
|August 29, 2002
Abstract:
A total synthesis of phomactin A (1) based on a Cr(II)/Ni(II) macrocyclisation from the aldehyde vinyl iodide 11, leading to 12, followed by elaboration of the epoxyketone 16, which then undergoes spontaneous pyran-hemiacetal formation on deprotection, is described.