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Related Experiment Videos

Overview: end-stage renal disease in the developing world.

Rashad S Barsoum1

  • 1Kasr-El-Aini School of Medicine, Cairo University, Cairo, Egypt. rbasoum@msn.com

Artificial Organs
|August 29, 2002
PubMed
Summary

End-stage renal disease (ESRD) is highly prevalent in developing nations, with glomerulonephritis as a leading cause. Limited funding restricts renal replacement therapy (RRT), leading to poorer outcomes and frequent complications.

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Area of Science:

  • Nephrology
  • Epidemiology
  • Public Health

Background:

  • The majority of end-stage renal disease (ESRD) patients reside in developing countries, yet epidemiological data and management strategies remain scarce.
  • Limited availability of credible and representative patient registries necessitates innovative approaches to gather essential information.

Purpose of the Study:

  • To investigate the epidemiology, etiology, and management of ESRD in developing countries.
  • To identify key trends and challenges in ESRD care within these regions.

Main Methods:

  • A collaborative effort involving leading nephrologists from 10 developing countries.
  • A 103-item questionnaire was administered to gather data on ESRD epidemiology, etiology, and management, integrating information from various sources.

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Main Results:

  • High ESRD prevalence was observed, correlated with national wealth, despite restricted access to renal replacement therapy (RRT).
  • Glomerulonephritis, not diabetes, is the primary cause of ESRD, with notable geographical variations in histopathological types.
  • Funding limitations significantly hinder RRT implementation; hemodialysis is prevalent, except in Mexico (CAPD). Treatment outcomes are generally inferior to international standards, often due to infections and cardiovascular issues.

Conclusions:

  • ESRD poses a significant burden in developing countries, characterized by limited RRT access and suboptimal treatment outcomes.
  • Glomerulonephritis is a major etiological factor, necessitating further research into its specific histopathological types and geographical distribution.
  • Addressing funding gaps and improving RRT infrastructure are crucial for enhancing ESRD patient care and outcomes in resource-limited settings.